Dinsley Street, between Coombs Street and Morris Street, was reopened just before 8 a.m. on Sunday.
Drivers were urged to avoid the area as emergency services in Blyth investigated a fire.
Huron County Ontario Provincial Police (OPP) said that they received the report of a residential fire late Saturday night.
Emergency crews responded to the blaze at about 11:45 p.m.
Police said the resident of the home was able to get out safely.
The investigation is ongoing.
Anyone with information is asked to contact the OPP at 1-888-310-1122 or Crime Stoppers at 1-800-222-8477 (TIPS).